- Original Article
- Allergy
- Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a common data model
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Ji Eun Lim, Hye Min Kim, Ju Hee Kim, Hey Sung Baek, Man Yong Han
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Clin Exp Pediatr. 2023;66(8):357-365. Published online June 14, 2023
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Question: Is dyslipidemia a risk factor for asthma in children?
Finding: This was a comprehensive systematic review and retrospective multicenter study of the association between dyslipidemia and asthma in children. In a multicenter cohort analysis using the Observational Medical Outcomes Partnership Common Data Model, elevated total cholesterol levels were associated with increased risk of asthma development.
Meaning: These findings suggest an association between dyslipidemia and asthma in children. |
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- Editorial
- Other
- Advancing pediatric health: the multifaceted scope of Clinical and Experimental Pediatrics
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Jin Hee Oh, Man Yong Han
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Clin Exp Pediatr. 2023;66(4):171-172. Published online March 29, 2023
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Clinical and Experimental Pediatrics (CEP) is a journal that specializes in pediatric research topics. It covers a wide range of research areas, including basic research, translational research, and research related to improving pediatric health and diseases. CEP also focuses on the coordination of societal structures and processes that orchestrate pediatric health and disease throughout society, and the parallel relationship between regional characteristics and globalization. The journal intends to continue promoting pediatric health through relentless efforts and the discovery of new research areas. |
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- Original Article
- Infection
- Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study
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In Suk Sol, Eun Lee, Hyeon-Jong Yang, Yong Ju Lee, Hye Yung Yum, Mi-Hee Lee, Mi Ae Chu, Hui Jeong Moon, Hyo-Bin Kim, Ju Hee Seo, Jung Yeon Shim, Ji Young Ahn, Yoon Young Jang, Hai Lee Chung, Eun Hee Chung, Kyunghoon Kim, Bong-Seong Kim, Cheol Hong Kim, Yang Park, Meeyong Shin, Kyung Suk Lee, Man Yong Han, Soo-Jong Hong, Eun Kyeong Kang, Chang Keun Kim; on behalf of The Pneumonia & Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease
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Clin Exp Pediatr. 2023;66(3):134-141. Published online December 22, 2022
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Question: The clinical differences between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and human coronaviruses (HCoV) in children remain unknown.
Finding: This study compared the clinical findings of children infected with SARS-CoV-2 versus HCoV. Its findings suggest that children and adolescents with SARS-CoV-2 have a milder clinical course than those with HCoV.
Meaning: The clinical course of children and adolescents with SARS-CoV-2 should be closely monitored during the coronavirus disease 2019 pandemic. |
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- Review Article
- Pulmonology
- Long COVID in children and adolescents: prevalence, clinical manifestations, and management strategies
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Eun Kyo Ha, Ju Hee Kim, Man Yong Han
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Clin Exp Pediatr. 2023;66(11):465-474. Published online June 19, 2023
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· Current definitions of long coronavirus disease (COVID) in children and adolescents vary in duration, ranging from 4 to 12 weeks or more.
· The clinical spectrum of long COVID in children and adolescents comprises a wide range of symptoms and might be a multisystem disorder.
· Persistent health problems with a prevalence of 1%–66.5% were reported in children and adolescents after COVID-19, with a higher incidence of persistent single or multiple symptoms. |
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- Allergy
- Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008)
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Ju Hee Kim, Jung Eun Lee, So Min Shim, Eun Kyo Ha, Dong Keon Yon, Ok Hyang Kim, Ji Hyeon Baek, Hyun Yong Koh, Kyu Young Chae, Seung Won Lee, Man Yong Han
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Clin Exp Pediatr. 2021;64(9):480-488. Published online January 5, 2021
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This national cohort study included all Korean children born in 2008 and 2009 observed over a period of more than 10 years. Our findings demonstrate that it is possible to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors by integrating National Health Insurance System data with national health screening data. |
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- Review Article
- Allergy
- Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis
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Hye Yung Yum, Eun Kyo Ha, Yoon Ho Shin, Man Yong Han
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Clin Exp Pediatr. 2021;64(8):373-383. Published online August 10, 2020
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Rhinitis is among the most common respiratory diseases in children. Nonallergic rhinitis, which involves nasal symptoms without evidence of systemic allergic inflammation or infection, is a heterogeneous entity with diverse manifestations and intensities. Nonallergic rhinitis accounts for 16%–89% of the chronic rhinitis cases, affecting 1%–50% (median 10%) of the total pediatric population. The clinical course of nonallergic rhinitis is generally... |
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- Original Article
- Pulmonology
- Clinical predictors of chest radiographic abnormalities in young children hospitalized with bronchiolitis: a single center study
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Ga Ram Kim, Min Sun Na, Kyung Suk Baek, Seung Jin Lee, Kyung Suk Lee, Young Ho Jung, Hye Mi Jee, Tae Hee Kwon, Man Yong Han, Youn Ho Sheen
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Clin Exp Pediatr. 2016;59(12):471-476. Published online December 31, 2016
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Purpose Chest radiography is often performed on patients hospitalized with typical clinical manifestations of bronchiolitis. We aimed to determine the proportion of subjects with pathologic chest radiographic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis. MethodsWe obtained the following data at admission: sex, age, neonatal history, past history of... |
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- Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children
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Na Yeon Kim, Ga Ram Kim, Joon Hwan Kim, Ji Hyeon Baek, Jung Won Yoon, Hye Mi Jee, Hye Sung Baek, Yong Ho Jung, Sun Hee Choi, Ki Eun Kim, Youn Ho Shin, Hye Yung Yum, Man Yong Han, Kyu-Earn Kim
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Clin Exp Pediatr. 2015;58(9):330-335. Published online September 21, 2015
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Purpose The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies. MethodsThe study included children <10 years of age with... |
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- Clinical risk factors associated with the development of wheezing in children less than 2 years of age who required hospitalization for viral lower respiratory tract infections
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Joon Hwan Kim, Ji-Yeon Choi, Na Yeon Kim, Jin Woo Kim, Ji Hyeon Baek, Hye Sung Baek, Jung Won Yoon, Hye Mi Jee, Sun Hee Choi, Hyeung Yoon Kim, Ki Eun Kim, Youn Ho Shin, Man Yong Han
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Clin Exp Pediatr. 2015;58(7):245-250. Published online July 22, 2015
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Purpose Wheezing following viral lower respiratory tract infections (LRTIs) in children <2 years of age is an important risk factor for the development of asthma later in life; however, not all children with viral LRTIs develop wheezing. This study investigated risk factors for the development of wheezing during viral LRTIs requiring hospitalization. MethodsThe study included 142 children <2 years of age hospitalized... |
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- Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants
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Choae Lee, Jaewoo An, Ji Hee Kim, Eun Sun Kim, Soo Hyun Kim, Yeon Kyung Cho, Dong Hyun Cha, Man Yong Han, Kyu Hyung Lee, Youn Ho Sheen
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Clin Exp Pediatr. 2015;58(11):415-420. Published online November 22, 2015
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Purpose Bronchopulmonary dysplasia (BPD) is characterized by inflammation with proteolytic damage to the lung extracellular matrix. The results from previous studies are inconsistent regarding the role of proteinases and antiproteinases in the development of BPD. The aim of the present study was to investigate whether matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-1 levels in the serum of... |
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- Review Article
- Determinants of sensitization to allergen in infants and young children
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Hyeong Yun Kim, Youn Ho Shin, Man Yong Han
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Clin Exp Pediatr. 2014;57(5):205-210. Published online May 31, 2014
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Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children. Additionally, with increasing age, the prevalence of sensitization to inhalant allergens and the prevalence of polysensitization to allergens increase. It is also well established that the development of atopic sensitization is the result of a complex interplay of genetic... |
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- Original Article
- Prevalence and comorbidity of allergic diseases in preschool children
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Hyeong Yun Kim, Eun Byul Kwon, Ji Hyeon Baek, Youn Ho Shin, Hye Yung Yum, Hye Mi Jee, Jung Won Yoon, Man Yong Han
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Clin Exp Pediatr. 2013;56(8):338-342. Published online August 27, 2013
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Purpose Allergic disease and its comorbidities significantly influence the quality of life. Although the comorbidities of allergic diseases are well described in adult populations, little is known about them in preschool children. In the present study, we aimed to assess the prevalence and comorbidity of allergic diseases in Korean preschool children. MethodsWe conducted a cross-sectional study comprising 615 Korean children (age, 3... |
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- Antibody response to pneumococcal vaccination in children with chronic or recurrent rhinosinusitis
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Ji Hyeon Baek, Hyun Kyong Seo, Hye Mi Jee, Youn Ho Shin, Man Yong Han, Eun Sang Oh, Hyun Ju Lee, Kyung Hyo Kim
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Clin Exp Pediatr. 2013;56(7):286-290. Published online July 19, 2013
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Purpose Although chronic and recurrent rhinosinusitis is prevalent in children, little is known about its causes. Here, we investigated the humoral immunity in children with chronic or recurrent rhinosinusitis. MethodsWe examined 16 children attending the outpatient clinic at the CHA Bundang Medical Center including 11 boys and 5 girls, aged 3.11 years (mean age, 5.6 years), who had rhinosinusitis for >3 months... |
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- Reference values for respiratory system impedance using impulse oscillometry in healthy preschool children
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Jye Hae Park, Jung Won Yoon, Youn Ho Shin, Hye Mi Jee, Young Sun Wee, Sun Jung Chang, Jung Hwa Sim, Hye Yung Yum, Man Yong Han
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Clin Exp Pediatr. 2011;54(2):64-68. Published online February 28, 2011
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Purpose The normal values for lung resistance and lung capacity of children, as determined by impulse oscillometry (IOS), are different for children of different ethnicities. However, reference values there is no available reference value for Korean preschool children have yet to be determined. The aim of the present study was to determine the normal ranges of IOS parameters in Korean preschool... |
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- Increased B cell-activating factor (BAFF) level in the sputum of children with asthma
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Hye Mi Jee, Bong Seok Choi, Kyung Won Kim, Myung Hyun Sohn, Man Yong Han, Kyu-Earn Kim
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Clin Exp Pediatr. 2010;53(8):795-800. Published online August 31, 2010
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Purpose B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naïve cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary... |
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- Analysis of reports on orphan lung diseases in Korean children
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Sun Jung Jang, Hyun Kyung Seo, Sung Jae Yi, Kyong Min Kim, Hye Mi Jee, Man Yong Han
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Clin Exp Pediatr. 2010;53(6):711-717. Published online June 23, 2010
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Purpose Orphan lung diseases are defined as lung diseases with a prevalence of 1 or less in 2,000 individuals. Despite an increase in the numbers of patients with such diseases, few studies on Korean children have appeared. To obtain epidemiologic and demographic data on these diseases, we systematically reviewed reports on pediatric orphan lung diseases in Korea over the last 50... |
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- Toll-like receptor 9 expression and interferon-α secretion upon
CpG-ODN stimulation in allergic subjects
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Man Yong Han, Hye Mi Jee, Hyeong Yoon Kim, Cho Ae Lee, Hyo-Jin Cho, Seong-Gyu Hwang, Kyu-Earn Kim
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Clin Exp Pediatr. 2009;52(9):1015-1020. Published online September 15, 2009
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Purpose:The aim of this study is to explore the effect of the Toll-like receptor 9 (TLR9) expressed in plasmacytoid dendritic cells (pDCs) that respond to antigen to Th2 immune deviation in allergic patients.
Methods:Subjects consisted of 19 allergic patients and 17 healthy volunteers. Skin prick tests and nasal provocation tests were performed for the two groups. Peripheral blood mononuclear cells (PBMCs)... |
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- The quality control and acceptability of spirometry in preschool children
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Hyun Kyong Seo, Sun Jung Chang, Da Woon Jung, Young Sun Wee, Hye Mi Jee, Ji Young Seo, Man Yong Han
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Clin Exp Pediatr. 2009;52(11):1267-1272. Published online November 15, 2009
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Purpose : We examined the ability of preschool aged children to meet the American Thoracic Society (ATS) and European Resiratory Society (ERS) goals for spirometry quality and tried to find out the major factor for improving the rate of success of spiromety test in this age group.
Methods : Spirometry was performed in 2-6 aged 155 children with chronic cough or... |
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- Case Report
- Pulmonary arteriovenous malformation manifesting with perioral cyanosis and dyspnea on exertion: A case report
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Yu Kyung Kim, Jin Woo Kim, Gun Lee, Man Yong Han
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Clin Exp Pediatr. 2009;52(1):124-128. Published online January 15, 2009
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Pulmonary arteriovenous malformations (PAVMs) are direct communications between pulmonary arteries and pulmonary veins, resulting in right-to-left shunts that may cause cyanosis, dyspnea, and digital clubbing. Neurological complications such as intracerebral hemorrhage or brain abscess may result from cerebral thrombosis or emboli. In most cases, they remain unrecognized until the late teenage years. Here, we report a case of a 6-year-old... |
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- Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report
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Se Eun Hyun, Pil Joo Hwang, Kyung Pil Nam, Eun Gyong Yoo, Man Yong Han
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Clin Exp Pediatr. 2008;52(3):385-388. Published online March 15, 2009
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An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the... |
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- Original Article
- A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children
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Hae Young Hur, Ji Hee Kwak, Hyoung Yun Kim, Da Wun Jung, Yoon Ho Shin, Man Yong Han
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Clin Exp Pediatr. 2008;51(8):842-847. Published online August 15, 2008
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Purpose : Measurement of forced expiratory volume in 1 second (FEV1) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with FEV1.
Methods : We studied 174 children who performed the lung function and methacholine challenge... |
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- Safety and efficacy of the ultra-rush immunotherapy with extracts of Dermatophagoides pteronyssinus in children
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Sei Eun Hyun, Hyoung Yun Kim, Ji Hee Kwak, Youn Ho Shin, Ji Yeong Seo, Man Yong Han
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Clin Exp Pediatr. 2008;51(8):868-873. Published online August 15, 2008
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Purpose : Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children.
Methods : Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive... |
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- Reference values for respiratory system impedance using impulse oscillometry in school-aged children in Korea
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Young Sun Wee, Hyoung Yun Kim, Da Wun Jung, Hye Won Park, Yoon Ho Shin, Man Yong Han
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Clin Exp Pediatr. 2007;50(9):862-867. Published online September 15, 2007
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Purpose : The impulse oscillometry (IOS) is applicable to young children because it requires minimal cooperation and a non-invasive method to measure the mechanics of respiratory system. This study aimed to develop the reference values in school-aged children in Korea, using IOS which is a modification of forced oscillation technique (FOT).
Methods : Measurements were performed in 92 previously untrained healthy... |
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- Original Article
- Estimation of the Possible Age for Using Various Types of
Inhaler by In-Check Inspiratory Flow Meter(TM)
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Kyung Hyun Jung, Sun Ye Kim, Jun Ho Lee, Kye Sung Kim, Yook Jang, Man Yong Han
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Clin Exp Pediatr. 2002;45(2):192-198. Published online February 15, 2002
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Purpose : It is important to select and use kinds of Inhaler appropriate to the age of the patient and severity of symptoms. Several kinds of Inhaler have been developed and recommended according to each inhaler's resistance and usage method. We evaluated the usable age of 4 inhalers (turbulent flow inhalers, multi unit dose inhalers, breath actuated MDI, and autohalers)... |
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- Case Report
- Five Cases of Prader-Willi or Angelman Syndrome Diagnosed by FISH in Neonate and Infancy
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Hee Jung Chung, Young Rae Kim, Man Yong Han, Sook Hwan Lee
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Clin Exp Pediatr. 2000;43(3):417-422. Published online March 15, 2000
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The Prader-Willi syndrome(PWS) and Angelman syndrome(AS) are clinically distinct syndromes with a shared cytogenetic deletion of chromosome 15q11q13 in most patients. Currently the diagnosis of PWS/AS is clinically suspected and can be confirmed by genetic laboratory tests. However, their diagnosis remains difficult in neonates and early infants because many features of the syndromes change with age and the typical features... |
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